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June 12, 2026NeuroImage ClinicalOpen Access

Multimodal magnetic resonance imaging-based clustering identifies two imaging-defined brain phenotypes in De novo Parkinson's disease

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Authors

EAEsraa ArabiYTYuan TIANMZMinwei Zhu

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Overview

Randomized trial identifies two imaging-defined subtypes in de novo Parkinson's disease, highlighting cognitive variability.

Key Points

  • The study aims to identify imaging-defined subtypes of Parkinson's disease that demonstrate clinical and cognitive variability.
  • Analyzed baseline neuroimaging data from 103 de novo PD participants and 40 normal controls from PPMI.
  • Extracted 209 imaging features using diffusion and structural MRI, adjusting for confounders.
  • Employed hierarchical clustering with Ward's linkage and validated using Silhouette and Calinski–Harabasz indices.
  • Subtype A has higher fractional anisotropy (FA) and lower mean diffusivity (MD), with stable cognitive scores over 48 months.
  • Subtype B shows increased MD and lower cognitive performance, exhibiting significant cognitive decline over time.
  • Identified two distinct imaging-defined phenotypes that correlate with cognitive progression in early Parkinson's disease.

Cite This Study

Arabi et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba18c8101cf8926f00f5chttps://doi.org/10.1016/j.nicl.2026.104021
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