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June 12, 2026ACS Sensors

A Polarity-Sensitive Lipid Droplet Probe Reveals Aβ Species-Dependent Lipid Droplet Remodeling in Microglia

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Authors

PHPanyi HuSGShuo GuoYRYouxiang Ren

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Overview

Randomized trial examines lipid droplet changes in microglia, suggesting monomeric Aβ impacts function.

Key Points

  • To investigate the effects of different Aβ species on lipid droplet remodeling in microglia.
  • Used polarity-sensitive LD probe BODIPY-LD for visualization of lipid droplets.
  • Analyzed hippocampal microglia from APP/PS1 mice and BV2 microglial cells.
  • Evaluated the influence of monomeric, oligomeric, and fibrillar Aβ 25−35 on LD accumulation.
  • BV2 cells treated with monomeric Aβ 25−35 showed the highest LD enrichment compared to other species.
  • LD-rich phenotype correlated with reduced phagocytic capacity in microglia.
  • Inhibition of LD synthesis using Triacsin C partially reversed the impaired phagocytic function.

Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba1ca8101cf8926f0104chttps://doi.org/10.1021/acssensors.6c01055
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