Key result
Highest VAT quartile linked to ~34 points higher fatty liver index in non-obese older adults.
Why the study?
In older adults, BMI may underestimate clinically relevant adiposity due to age-related lean mass loss and preferential accumulation of visceral and ectopic fat.
Does DXA-derived visceral adipose tissue identify hidden liver-metabolic risk beyond BMI in non-obese older adults?
Cross-Sectional (n=891)
Does DXA-derived visceral adipose tissue identify hidden liver-metabolic risk beyond BMI in non-obese older adults?
Mean Difference: 33.9 (95% CI 28.72–39.08)
DXA-derived regional adiposity identifies hidden liver-metabolic vulnerability beyond BMI in non-obese older adults.
VAT assessment may aid fatty liver risk stratification; leaves open causality and clinical utility pending prospective studies.
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Perna et al. (2026) conducted a cross-sectional in Hidden liver-metabolic risk in non-obese older adults (n=891). High DXA-derived visceral adipose tissue (VAT) vs. Low DXA-derived visceral adipose tissue (VAT) was evaluated on Non-invasive steatosis scores, namely fatty liver index (FLI) and hepatic steatosis index (HSI) (beta 33.90 for FLI, 95% CI 28.72 to 39.08). The highest quartile of DXA-derived visceral adipose tissue was associated with a higher fatty liver index (beta +33.90; 95% CI 28.72 to 39.08) compared to the lowest in non-obese older adults.
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