What question did this study set out to answer?

This study aims to evaluate the effects of vancomycin-loaded PMMA versus vancomycin-SC on inflammatory responses and clinical outcomes in chronic osteomyelitis.

June 12, 2026Annals of MedicineOpen Access

A retrospective cohort study comparing the effects on inflammatory response and clinical outcomes of vancomycin-PMMA versus vancomycin-sulfate calcium in chronic osteomyelitis

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Authors

韩韩殊曼Hebei Medical University XWXirui WuSoochow University TWTao WuHebei Medical University

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Implication

Retrospective cohort study shows improved clinical outcomes in chronic osteomyelitis with vancomycin-SC, suggesting better treatment options.

Key Points

This study aims to evaluate the effects of vancomycin-loaded PMMA versus vancomycin-SC on inflammatory responses and clinical outcomes in chronic osteomyelitis.
Retrospective cohort study of 244 patients treated for chronic osteomyelitis between January 2017 and December 2024.
Patients divided into two treatment groups: PMMA (n=126) and PMMA-SC (n=118).
Postoperative outcomes, inflammatory markers, and quality of life were assessed.
PMMA-SC group had higher infection control rates (87.29% vs. 72.22%, p=0.004).
Reoperation rates were lower in PMMA-SC group (7.63% vs. 21.43%, p=0.002).
Overall complication rate was significantly lower in the PMMA-SC group (8.47% vs. 26.19%, p<0.001).

Cite This Study

韩殊曼 et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba1ca8101cf8926f01104 https://doi.org/10.1080/07853890.2026.2680392

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Implication

Retrospective cohort study shows improved clinical outcomes in chronic osteomyelitis with vancomycin-SC, suggesting better treatment options.

A retrospective cohort study comparing the effects on inflammatory response and clinical outcomes of vancomycin-PMMA versus vancomycin-sulfate calcium in chronic osteomyelitis

Discussion

Member takes

Implication

Key Points

Cite This Study

A retrospective cohort study comparing the effects on inflammatory response and clinical outcomes of vancomycin-PMMA versus vancomycin-sulfate calcium in chronic osteomyelitis

Discussion

Member takes

Implication

Key Points

Cite This Study

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