Key result
A 10-point increase in cardiovascular health score is linked to up to ~24% lower CVD risk.
Why the study?
The relative importance and biological mechanisms of modifiable risk factors for cardiovascular diseases remain unclear among adults with hypertension.
Do more favorable modifiable risk factor profiles reduce the incidence of cardiovascular diseases in adults with hypertension?
Population
134,417 adults with hypertension
Comparison
Individual and joint modifiable risk factors assessed via cardiovascular health score
Design
Prospective cohort study
Follow-up
Median 13.26 years
Authors
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Supports risk factor optimization to lower TIA incidence; extends large observational data but leaves causality and practice change open.
Cohort (n=134,417)
Do more favorable modifiable risk factor profiles reduce the incidence of cardiovascular diseases in adults with hypertension?
Effect estimate: HR 0.76 to 0.92 (95% CI 0.72-0.79 to 0.87-0.97)
In adults with hypertension, nicotine exposure and BMI are the leading modifiable risk factors for cardiovascular disease, with inflammation-related pathways potentially mediating these effects.
Wei et al. (2026) conducted a cohort in Hypertension (n=134,417). Modifiable risk factors (cardiovascular health score) vs. Lower cardiovascular health score was evaluated on Incidence of eight cardiovascular diseases (HR 0.76 to 0.92, 95% CI 0.72-0.79 to 0.87-0.97). A 10-point increase in cardiovascular health score lowered cardiovascular disease risk (HRs 0.76-0.92), while nicotine exposure had the largest population attributable fraction (7.9%-36.4%).
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