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June 12, 2026PLoS ONEOpen Access

Incidence and predictors of neonatal hyperbilirubinemia requiring phototherapy: A prospective cohort study at a tertiary hospital in Uganda

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Cohort study identifies risk factors for hyperbilirubinemia in neonates, suggesting preventative measures.

This study aimed to determine the incidence and predictors of neonatal hyperbilirubinemia requiring phototherapy at a referral hospital in Uganda.
Prospective cohort study conducted from November 2024 to February 2025.
539 mother-infant pairs enrolled, with 534 completing follow-up.
Data collected included maternal and neonatal characteristics, total serum bilirubin, and ABO/Rh blood grouping.
20% of neonates developed hyperbilirubinemia requiring phototherapy.
Increased risk associated with underweight mothers (aIRR = 1.703, P = 0.021) and preterm neonates (aIR = 2.776, P < 0.001).
ABO incompatibility significantly increased the risk (aIRR = 2.985, P < 0.001).

Yusuf et al. (2026) studied this question.

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