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This review aims to elucidate the immunobiological impact of clonal hematopoiesis of indeterminate potential (CHIP) on gastrointestinal disorders.

Current Understanding of CHIP’s Immunobiological Footprint with A Focus on Gastrointestinal Disorders: A Review of the Literature

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This review aims to elucidate the immunobiological impact of clonal hematopoiesis of indeterminate potential (CHIP) on gastrointestinal disorders.
Review of literature concerning CHIP's genetic mutations and their effects on inflammation and cancer.
Analysis of interactions between hematopoietic clones and gastrointestinal pathologies.
Focus on gene-specific mechanisms related to gastrointestinal inflammation and malignancy.
CHIP mutations, particularly in TET2 and DNMT3A, enhance IL-6 signaling, promoting hepatic inflammation and fibrosis.
TET2-mutant CHIP is linked to severe phenotypes in inflammatory bowel disease.
Mutant macrophages from CHIP alter tumor immune microenvironments, affecting colorectal cancer progression and therapy response.

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Review explores CHIP's impact on inflammation and cancer in the gastrointestinal tract, suggesting new treatment approaches.

Arora et al. (2026) studied this question.

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