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June 12, 2026Advanced ScienceOpen Access

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

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Authors

JSJialiang SunJilin UniversityWYWeijing YangSoochow UniversityHZHao ZhouJilin University

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Overview

Randomized trial shows RNF138 restricts viral replication in TBEV-infected mice, indicating a novel antiviral mechanism.

Key Points

  • This study aims to elucidate the role of RNF138 in restricting tick-borne encephalitis virus replication through ubiquitin-mediated degradation of NS5.
  • Identified RNF138 as an E3 ubiquitin ligase targeting TBEV NS5.
  • Conducted mutational analyses to determine ubiquitination sites on NS5.
  • Utilized mouse models to assess the impact of RNF138 on viral replication and neuroinflammatory responses.
  • RNF138 catalyzes K48-linked polyubiquitination leading to degradation of NS5.
  • Ectopic RNF138 reduces viral RNA levels in infected mice, improving survival rates.
  • Mutating ubiquitination sites on NS5 results in resistance to RNF138-induced degradation.

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba4a18101cf8926f030c3https://doi.org/10.1002/advs.75991
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