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August 12, 2026Journal of VirologyOpen Access

Nuclear activities and interactome of the NS5 protein of tick-borne encephalitis virus

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Authors

MCMaxime ChazalASAïssatou Aïcha SowESElodie Le Seac’h

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Overview

Randomized trial uncovers nuclear localization effects on viral replication in tick-borne encephalitis virus, suggesting new pathways for targeting.

Key Points

  • This research aims to elucidate the nuclear activities and interactions of the NS5 protein in tick-borne encephalitis virus.
  • Microscopy analysis and cell fractionation analyzed NS5 localization to cytoplasm and nucleoplasm.
  • Mutagenesis studies identified critical residues necessary for nuclear targeting of NS5.
  • Immunoprecipitation-mass spectrometry analyzed NS5 interactors in infected human cell lines.
  • NS5 localized in both cytoplasm and nucleoplasm of infected cells.
  • Critical residues for nuclear targeting, when mutated, abolished viral replication.
  • Identified 352 NS5 interactors, with 187 being nuclear, including factors that modulate viral replication.

Cite This Study

Chazal et al. (2026) studied this question.

synapsesocial.com/papers/6a7c203e06a85aed514b719ehttps://doi.org/10.1128/jvi.00810-26
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection2026
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  3. 3[The NS1 Protein of the Tick-Borne Encephalitis Virus and Extracellular Vesicles from NS1-Expressing Cells: Effect on Expression of Genes of the Innate Immune Response in Neuroblastoma and Glioblastoma Cells].2025
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  5. 5Selection Pressure Profile Suggests Species Criteria among Tick-Borne Orthoflaviviruses2024