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September 10, 2025

The NS1 Protein of the Tick-Borne Encephalitis Virus and Extracellular Vesicles from NS1-Expressing Cells: Effect on Expression of Genes of the Innate Immune Response in Neuroblastoma and Glioblastoma Cells.

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Authors

YKY. V. KuzmenkoALAnastasia LatanovaВКВ. Л. Карпов

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Overview

Observational analysis reveals NS1 protein modifies innate immune expression in neuroblastoma and glioblastoma, suggesting potential therapeutic targets.

Key Points

  • NS1 protein from tick-borne encephalitis virus reduces expression of several key pro-inflammatory cytokines.
  • Transfection with NS1 led to decreased IL-1β and TNF-α mRNA in neuroblastoma cells when stimulated.
  • Extracellular vesicles from NS1-expressing cells increased pro-inflammatory cytokines in neuroblastoma, indicating a dual role.
  • Findings suggest that targeting NS1 could be a promising strategy for neuroinflammatory conditions linked to TBEV.

Cite This Study

Kuzmenko et al. (2025) studied this question.

synapsesocial.com/papers/68c189ca9b7b07f3a0612d3ehttps://doi.org/10.31857/s0026898425030072
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[Expression of Nonstructural Protein 1 of the Tick-Borne Encephalitis Virus Stimulates the Secretion of Extracellular Vesicles Capable of Activating IL-1β Production].2025
  2. 2Interactions between tick-borne encephalitis virus non-structural protein 1 and blood-brain barrier tight junction proteins: potential clues to strain-specific neuropathogenicity2025
  3. 3Nuclear activities and interactome of the NS5 protein of tick-borne encephalitis virus2026 · 1 citations
  4. 4Unraveling the role of human microglia in tick-borne encephalitis virus infection: insights into neuroinflammation and viral pathogenesis2024 · 9 citations
  5. 5Robust CXCL10/IP-10 and CCL5/RANTES Production Induced by Tick-Borne Encephalitis Virus in Human Brain Pericytes Despite Weak Infection2024 · 7 citations