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February 5, 2026npj VirusesOpen Access

Divergent roles of Hsp70 chaperones in orthoflavivirus protein secretion and virion formation

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Authors

LBLea BlankUniversity of Veterinary Medicine Hannover, FoundationCLChristin LorenzUniversity of Veterinary Medicine Hannover, FoundationISImke SteffenUniversity of Veterinary Medicine Hannover, Foundation

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Implication

Demonstrates how Hsp70 influences viral protein secretion in orthoflavivirus, suggesting potential antiviral strategies.

Key Points

  • The aim is to explore how Hsp70 chaperones and BiP affect the secretion and infectivity of orthoflaviviruses.
  • Examined interactions between orthoflavivirus proteins and Hsp70 chaperones
  • Targeted Hsp70 nucleotide-binding and substrate-binding domains with small-molecule inhibitors
  • Assessed NS1 secretion and viral infectivity in BiP-deficient cells
  • YM-1 significantly reduced infectivity of multiple orthoflaviviruses
  • PES-Cl impaired NS1 secretion specifically for tick-borne orthoflaviviruses
  • BiP is essential for NS1 secretion but not for viral infectivity

Cite This Study

Blank et al. (2026) studied this question.

synapsesocial.com/papers/698433e9f1d9ada3c1fb16cdhttps://doi.org/10.1038/s44298-026-00175-8
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