What question did this study set out to answer?

This study aims to assess the value of p57 immunohistochemistry in distinguishing between complete and partial hydatidiform moles and non-molar pregnancies.

June 12, 2026CureusOpen Access

Resolving Morphological Ambiguity in Molar Pregnancy: The Diagnostic Role of p57 Immunohistochemistry

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Authors

ANAnanya NathShri BM Patil Medical College SNSavitri M NeruneShri BM Patil Medical College SDSayandeep K. DasShri BM Patil Medical College

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Implication

Cross-sectional study evaluates p57 immunohistochemistry for diagnosing molar versus non-molar pregnancies, suggesting improved clinical management.

Key Points

This study aims to assess the value of p57 immunohistochemistry in distinguishing between complete and partial hydatidiform moles and non-molar pregnancies.
Cross-sectional study with 60 diagnosed cases of complete hydatidiform mole, partial hydatidiform mole, and non-molar pregnancies.
Tissue samples were analyzed with H&E staining and evaluated using p57 immunohistochemistry.
Statistical analyses were performed with a significance level set at p < 0.05.
All non-molar cases exhibited positive p57 expression.
Among molar pregnancies, 91.7% of complete hydatidiform moles were p57 negative, whereas 78.6% of partial hydatidiform moles were p57 positive.
p57 immunohistochemistry led to reclassification in 13.3% of cases, with a significant association between diagnosis and p57 expression (p < 0.001).

Cite This Study

Nath et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba4d68101cf8926f031a9 https://doi.org/10.7759/cureus.110606

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Implication

Cross-sectional study evaluates p57 immunohistochemistry for diagnosing molar versus non-molar pregnancies, suggesting improved clinical management.

Resolving Morphological Ambiguity in Molar Pregnancy: The Diagnostic Role of p57 Immunohistochemistry

Discussion

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Implication

Key Points

Cite This Study

Resolving Morphological Ambiguity in Molar Pregnancy: The Diagnostic Role of p57 Immunohistochemistry

Discussion

Member takes

Implication

Key Points

Cite This Study

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