Case report highlights atypical cognitive decline and seizure onset in autoimmune encephalitis, suggesting improved diagnosis.
Autoimmune encephalitis typically presents with an acute or subacute onset of cognitive decline, altered mental status, and seizures. Here, we report a case of anti-leucine-rich glioma-inactivated 1 encephalitis characterized by an atypically protracted period of cognitive decline, followed by the delayed onset of seizures. We describe the clinical characteristics, unique neuroimaging findings, and the patient’s response to treatment. By discussing the implications of this unusual clinical trajectory, we aim to enhance diagnostic awareness and prevent potential misdiagnosis in cases with atypically prolonged presentations.
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Park et al. (2026) studied this question.
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