Demonstrates reduced amyloid-β pathology in Alzheimer's with ALKBH3 demethylase deficiency, suggesting a potential therapeutic angle.
Alzheimer's Disease The cover illustrates how ALKBH3 demethylates PINK1 mRNA at m1A sites, destabilizing PINK1 transcripts and suppressing mitophagy, which drives Alzheimer's pathology (winter scene). Restoring ALKBH3 function rescues mitophagy (spring scene), with PINK1 (pink flower) facilitating mitochondrial transport along neurites (branches). More details can be found in the Research Article by Magdalena J. Koziol and co-workers (DOI: 10.1002/advs.202522572). Image credit: Li Jiayue, Li Yueyang, and Mingje Dong.
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