Key result
GCKR rs780094 CT+TT genotype linked to ~71% higher odds of diabetic albuminuria.
Why the study?
Diabetic kidney disease is a common complication of type 2 diabetes with poor prognosis once albuminuria progresses, but its pathogenesis remains unclear and linked to genetic factors.
Does the GCKR gene rs780094 polymorphism increase the risk of albuminuria in patients with type 2 diabetes?
Cross-Sectional (n=318)
No
Does the GCKR gene rs780094 polymorphism increase the risk of albuminuria in patients with type 2 diabetes?
Odds Ratio: 1.71 (95% CI 1.172–2.493)
p-value: p=0.005
The presence of the CT + TT genotype in the GCKR rs780094 gene variant represents a significant genetic risk factor for the development of albuminuria in patients with type 2 diabetes.
CT+TT GCKR rs780094 genotype associated with albuminuria in T2D; leaves open causal role and clinical utility.
BACKGROUND Diabetic kidney disease is one of the common complications of type 2 diabetes (T2D). There are no typical symptoms in the early stage, and the disease will progress to moderate and late stage when albuminuria reaches a high level. Treatment is difficult and the prognosis is poor. At present, the pathogenesis of diabetic kidney disease is still unclear, and it is believed that it is associated with genetic and environmental factors. AIM To explore the relationship between the glucokinase regulatory protein (GCKR ) gene rs780094 polymorphism and T2D with albuminuria. METHODS We selected 252 patients (126 males and 126 females) with T2D admitted to our hospital from January 2020 to October 2020, and 66 healthy people (44 females and 22 males). According to the urinary albumin/creatinine ratio, the subjects were divided into group I (control), group II (T2D with normoalbuminuria), group III (T2D with microalbuminuria), and group IV (T2D with macroalbuminuria). Additionly, the subjects were divided into group M (normal group) or group N (albuminuria group) according to whether they developed albuminuria. We detected the GCKR gene rs780094 polymorphism (C/T) of all subjects, and measured the correlation between GCKR gene rs780094 polymorphism (C/T) and T2D with albuminuria. RESULTS Gene distribution and genotype distribution among groups I-IV accorded with the Hardy-Weinberg equilibrium. Genotype frequency was significantly different among the four groups (P = 0.048, χ 2 = 7.906). T allele frequency in groups II, III, and IV was significantly higher than that in group I. Logistic regression analysis of the risk factors for T2D with albuminuria showed that the CT + TT genotype (odds ratio = 1.710, 95% confidence interval: 1.172-2.493) was a risk factor. CONCLUSION CT + TT genotype is a risk factor for T2D with albuminuria. In the future, we can assess the risk of individuals carrying susceptible genes to delay the onset of T2D.
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Liu et al. (2023) conducted a cross-sectional in Type 2 diabetes with albuminuria (n=318). GCKR gene rs780094 CT + TT genotype vs. CC genotype was evaluated on Type 2 diabetes complicated with albuminuria (OR 1.710, 95% CI 1.172-2.493, p=0.005). The CT + TT genotype of the GCKR gene rs780094 was identified as an independent risk factor for type 2 diabetes complicated with albuminuria (OR 1.710).
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