Correlation between polymorphisms of SIRT2 gene and renal injury in patients with type 2 diabetes mellitus.

This is the authors' abstract. We don't add key points for this paper.

OBJECTIVES: genetic polymorphism and DKD susceptibility in T2DM patients, which may provide new ideas for the pathogenesis of DKD. METHODS: gene and risk of DKD in T2DM patients. According to the genotypes of rs11879029/rs11879010, T2DM patients were divided into a GG1/GG2 group, a GA1/GA2 group, and an AA1/AA2 group, and the clinical data were compared. Linkage disequilibrium analysis and haplotype analysis were performed. RESULTS: =0.008). CONCLUSIONS: gene are potential contributors to the susceptibility of DKD in patients with T2DM, and allele A significantly increases the risk of DKD compared with allele G. The AA genotype might be a genetic risk factor for DKD.