Key result
The GG genotype was an independent predictor of metabolic dysfunction-associated fatty liver disease in a Singapore Chinese population (P=0.014, AUC 0.823).
Why the study?
Genetic factors play an important role in MAFLD, but the association of SNPs identified in Western populations needed validation in an ethnic Chinese population alongside interactions with environmental and medical risk factors.
Are single nucleotide polymorphisms (SNPs) previously identified in Western populations associated with the risk of MAFLD in a Singapore Chinese population?
Observational
Are single nucleotide polymorphisms (SNPs) previously identified in Western populations associated with the risk of MAFLD in a Singapore Chinese population?
p-value: p== 0.014
Specific genetic variants (GG) are independent predictors of MAFLD in a Singapore Chinese population, extending findings from Western populations.
May support MAFLD risk stratification in Singapore Chinese; extends Western SNP associations but leaves open clinical utility pending validation.
BACKGROUND: Genetic factors play an important role in the pathogenesis and development of metabolic dysfunction-associated fatty liver disease (MAFLD). AIM: To study the association of single nucleotide polymorphisms (SNPs), previously identified in Western populations, with the risk of MAFLD in a Singapore Chinese population and their interactions with environmental and medical risk factors. METHODS: Predesigned SNP Genotyping Assay. RESULTS: = 0.014) were associated with MAFLD (area under the receiver operating characteristic curve of 0.823). CONCLUSION: GG are independent predictors of MAFLD.
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Lee et al. (2020) conducted an observational in Metabolic dysfunction-associated fatty liver disease (MAFLD). Single nucleotide polymorphisms (SNPs) / GG genotype was evaluated on Risk of MAFLD (p== 0.014). The GG genotype was an independent predictor of metabolic dysfunction-associated fatty liver disease in a Singapore Chinese population (P=0.014, AUC 0.823).
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