Key result
A detection panel comprising 12 key genetic loci associated with metabolic dysfunction-associated fatty liver disease in East Asian populations was successfully designed.
Why the study?
The study was conducted to design a panel of gene polymorphism detection of MAFLD in East Asian population based on current research.
Systematic Review
A newly designed 12-gene polymorphism panel may help identify genetic susceptibility to MAFLD in East Asian populations, though clinical validation is required.
Answers are grounded in this paper and cite their sources.
May guide East Asian MAFLD genetic panel development; leaves open prospective validation before clinical use.
The aim of this study was to design a panel of gene polymorphism detection of MAFLD in East Asian population based on current research. Literature search was conducted in PubMed database using the keywords "metabolism-related fatty liver" or "non-alcoholic fatty liver" and "Asia" or "East Asia" and "gene”. 41 studies met the inclusion criteria, and 12 key genetic loci were screened out involving FTO, KLB, PNPLA3, TRIB1, PPARα, LEPR, APOA5, TM6SF2, APOC3, GCKR, SREBP2, MTTP, associating with obesity, insulin resistance, glucose metabolism, fatty acid metabolism, and inflammatory fibrosis pathways. The panel was designed successfully, while the sensitivity and specificity remain to be further clinically validated.
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Ruopeng Wang (2022) conducted a systematic review in Metabolic dysfunction-associated fatty liver disease (MAFLD). Genetic polymorphisms associated with MAFLD vs. Individuals without the genetic polymorphisms was evaluated. A detection panel comprising 12 key genetic loci associated with metabolic dysfunction-associated fatty liver disease in East Asian populations was successfully designed.
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