A mortality risk stratification model for patients with acute heart failure

Q: What is the clinical evidence from this study?

Study design: Observational. Population: heart failure (NYHA Class III-IV) (n=647). Intervention: Clinical and biochemical factors. Primary outcome: mortality.

Q: What does this research mean for the field?

In patients with advanced heart failure, two-year mortality exceeds 45%, with unchanged NT-proBNP levels, lymphocyte percentage, and LDL-cholesterol levels serving as significant biochemical predictors of death. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

M Kouremeti; V Koulolia; E Agrotis; M Moustaka; N Katsanakis; D Fotellis; E Karathanou; K Mauromoustakou; C Fragoulis; C Chrysochoou; K Tsioufis

doi:10.1093/eurjpc/zwag249.055

June 1, 2026European Journal of Preventive CardiologyOpen Access

A mortality risk stratification model for patients with acute heart failure

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Why the study?

Heart failure carries high morbidity and mortality with poor prognosis, making reliable assessment of mortality risk crucial.

Key Points

Identify clinical and biochemical factors associated with mortality in patients with acute heart failure.
Retrospective observational study of 647 patients with heart failure (NYHA Class III-IV) hospitalized in 2022.
Factors assessed included demographics, hospitalization history, specific interventions, and biochemical markers.
Two-year follow-up to record mortality rates and correlations with various clinical factors.
Overall mortality rate was 45.74% with 296 deaths recorded during follow-up.
Significant associations found between mortality and factors like ischemic heart disease, significant valvular disease (55% mortality), and stable NT-proBNP levels (p=0.0004).
Lack of change in NT-proBNP and lymphocyte percentage are statistically significant predictors of mortality (p=0.0004 and p=0.04 respectively).

Study Design

Type

Observational (n=647)

PICO

P

Population

647 patients with advanced heart failure (NYHA Class III-IV) hospitalized for new or worsening symptoms, followed for two years.

E

Exposure / Comparator

Clinical and biochemical factors

O

Primary Outcome

mortality

Implication

Retrospective observational study identifies key mortality factors in patients with heart failure, suggesting critical risk stratification needs.

Discussion

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Cite This Study

Kouremeti et al. (2026) conducted an observational in heart failure (NYHA Class III-IV) (n=647). Clinical and biochemical factors was evaluated on mortality.

synapsesocial.com/papers/6a2bd11d6550ea4541ffe873 https://doi.org/10.1093/eurjpc/zwag249.055

Topics

Heart failure

HFrEF treatment

Heart failure hospitalization

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A mortality risk stratification model for patients with acute heart failure

Key Points

Study Design

PICO

Implication

Discussion

Cite This Study

Topics

A mortality risk stratification model for patients with acute heart failure

Key Points

Study Design

PICO

Implication

Discussion

Cite This Study

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Topics

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