Matrix metalloproteinases act as complex modulators of the tumor microenvironment in carcinogenesis, suggesting targeted inhibition of specific MMPs is required over non-selective approaches.
MMPs are versatile regulators of the tumor microenvironment, and their targeted inhibition based on specific MMPs and disease stages is likely necessary for effective cancer therapy.
Cancer remains a primary global health and economic challenge, characterized by complex mechanisms of carcinogenesis and metastasis. Central to these processes is the dysregulation of matrix metalloproteinases, a family of zinc-dependent proteases. While traditionally recognized for their role in extracellular matrix remodeling, MMPs are now understood as versatile regulators of both intra- and extracellular signaling. This review explores the characteristics and diverse functional roles of MMPs in representative cancers, highlighting their transition from simple matrix degraders to complex modulators of the tumor microenvironment. Current evidence indicates that non-selective inhibition of all MMPs is unlikely to be an effective therapeutic strategy. Instead, a more targeted approach focusing on specific MMPs and disease stages may be required.
Lewoc-Magnuszewska et al. (Thu,) conducted a review in Cancer. Matrix metalloproteinases (MMPs) was evaluated. Matrix metalloproteinases act as complex modulators of the tumor microenvironment in carcinogenesis, suggesting targeted inhibition of specific MMPs is required over non-selective approaches.