Key result
Type 1 diabetes leads to pulmonary vein ganglia remodeling with hypotrophy of sympathetic and parasympathetic cell bodies and a concomitant decrease in their activities compared to wild type.
Why the study?
Cardiac autonomic neuropathy causes adverse cardiovascular effects in diabetes, but pulmonary vein ganglia have not been fully investigated in type 1 diabetes mellitus.
Does type 1 diabetes mellitus cause anatomical remodeling and functional changes in pulmonary vein ganglia in a mouse model?
Does type 1 diabetes mellitus cause anatomical remodeling and functional changes in pulmonary vein ganglia in a mouse model?
Type 1 diabetes leads to anatomical hypotrophy and decreased sympathetic and parasympathetic activities in pulmonary vein ganglia in a mouse model.
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Hypothesis-generating for T1D-related arrhythmogenesis; leaves open translation to human PV ganglia and clinical AF risk.
Bassil et al. (2018) studied Type 1 diabetes mellitus. Type 1 diabetes vs. Wild type was evaluated on Pulmonary vein ganglia structure and function. Type 1 diabetes leads to pulmonary vein ganglia remodeling with hypotrophy of sympathetic and parasympathetic cell bodies and a concomitant decrease in their activities compared to wild type.
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