Key result
Chronic diabetes in OVE26 mice induced significant structural atrophy of vagal aortic afferent and cardiac efferent axons and terminals compared to age-matched controls (P < 0.05).
Why the study?
Does chronic type 1 diabetes induce structural atrophy of vagal aortic afferent and cardiac efferent axons and terminals in a transgenic mouse model?
Population
FVB control and OVE26 transgenic type 1 diabetic mice at 3, 6, and 9 months of age
Comparison
Type 1 diabetes disease model vs Age-matched FVB control mice
Design
Preclinical
Follow-up
Evaluated at 3, 6, and 9 months of age
Authors
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May indicate vagal remodeling in diabetic mice; leaves open human translation and functional impact.
Does chronic type 1 diabetes induce structural atrophy of vagal aortic afferent and cardiac efferent axons and terminals in a transgenic mouse model?
p-value: p=<0.05
Chronic type 1 diabetes induces significant structural atrophy of vagal aortic afferent and cardiac efferent axons and terminals in a transgenic mouse model, providing a structural basis for diabetes-induced cardiac autonomic impairment.
Li et al. (2010) studied Type 1 diabetes. Type 1 diabetes (OVE26 transgenic mouse model) vs. Age-matched FVB control mice was evaluated on Structural remodeling of vagal afferent innervation of aortic arch and nucleus ambiguus projections to cardiac ganglia (p=<0.05). Chronic diabetes in OVE26 mice induced significant structural atrophy of vagal aortic afferent and cardiac efferent axons and terminals compared to age-matched controls (P < 0.05).
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