Key result
Diabetic Goto-Kakizaki rats had a 39% lower total number of intracardiac neurons compared to metabolically healthy control rats (1461 vs 2395, p<0.001).
Observational (n=25)
No
Effect estimate: 39% reduction
Absolute Event Rate: 1461% vs 2395%
p-value: p=<0.001
Long-term diabetes in a rat model is associated with a significant reduction in the number and area of intracardiac ganglia, suggesting structural remodeling due to the diabetic state.
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May link diabetes to cardiac neuronal loss; hypothesis-generating for human autonomic neuropathy and requires clinical validation.
Batulevičius et al. (2013) conducted an observational in Type 2 Diabetes Mellitus (Animal Model) (n=25). Type 2 Diabetes (Goto-Kakizaki genetic model) vs. Metabolically healthy Wistar rats was evaluated on Total number of intracardiac neurons (39% reduction, p=<0.001). Diabetic Goto-Kakizaki rats had a 39% lower total number of intracardiac neurons compared to metabolically healthy control rats (1461 vs 2395, p<0.001).
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