May 25, 2011Artificial Organs
Exercise Capacity in Patients Supported With Rotary Blood Pumps Is Improved by a Spontaneous Increase of Pump Flow at Constant Pump Speed and by a Rise in Native Cardiac Output
Key result
Patients supported with continuous flow rotary blood pumps demonstrated significantly higher peak VO2 compared to matched heart failure patients (15.8 vs. 10.9 mL O2/kg.min).
Why the study?
Does continuous flow rotary blood pump support improve exercise capacity and hemodynamics compared to matched heart failure patients?
Population
20 patients total: 10 patients implanted with a continuous flow rotary blood pump and 10 matched heart…
Comparison
Continuous flow rotary blood pump support… vs Matched heart failure patients evaluated before…
Design
Cohort
Follow-up
6 months post-surgery (for RP group)
Authors
Discussion
Loading...
Member takes
Implication
Rotary pump support was associated with higher peak VO2 in advanced HF; hypothesis-generating and requires randomized confirmation before practice change.
Study Design
Type
Observational (n=20)
Structured PICO
Does continuous flow rotary blood pump support improve exercise capacity and hemodynamics compared to matched heart failure patients?
P
Population
20 patients, including 10 supported with a rotary blood pump 6 months post-surgery and 10 matched heart failure patients.
E
Exposure
Continuous flow rotary blood pump (RP) support, evaluated at 6 months post-surgery.
C
Comparator
Matched heart failure patients evaluated before transplantation.
O
Outcome
Peak VO2 and hemodynamic parameters (total output, pump flow, native cardiac output) during cardiopulmonary exercise testing (CPET).surrogate
Main Result
Absolute Event Rate: 15.8% vs 10.9%
Continuous flow rotary blood pumps significantly improve maximal exercise capacity in heart failure patients through both spontaneous increases in pump flow and native cardiac output.
Cite This Study
Jacquet et al. (2011) conducted an observational in Heart failure (n=20). Continuous flow rotary blood pumps vs. Matched heart failure patients was evaluated on Peak VO2. Patients supported with continuous flow rotary blood pumps demonstrated significantly higher peak VO2 compared to matched heart failure patients (15.8 vs. 10.9 mL O2/kg.min).