Key result
Global T2DM burden increases ~1% annually from 1990 to 2021, whereas T1DM burden decreases.
Why the study?
Diabetes mellitus poses a significant challenge to global health, warranting comparison of disease burden in the world's three most populous countries and projection of trends up to 2050.
Population
Global, Chinese, US, and Indian populations using GBD2021 data
Comparison
T1DM vs T2DM burden across China, US, India, and globally
Design
Bayesian age-period-cohort modeling study using GBD 2021 data
Authors
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May inform sex-stratified T2D surveillance; leaves open causal mechanisms and targeted interventions.
Observational
Effect estimate: AAPC 1.16 (95% CI 1.09 to 1.22)
p-value: p=<0.001
The global burden of T2DM is increasing, driven largely by population growth and aging, highlighting the need for targeted public health interventions, especially in India and the US.
Chen et al. (2025) conducted an observational in Diabetes mellitus. Diabetes mellitus was evaluated on Average annual percent change (AAPC) in global DALYs for Type 2 Diabetes Mellitus (AAPC 1.16, 95% CI 1.09 to 1.22, p=<0.001). From 1990 to 2021, the global burden of type 2 diabetes mellitus increased significantly, with an average annual percent change in DALYs of 1.16, whereas the type 1 diabetes burden decreased.
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