Key result
Among offspring with cardiac neonatal lupus, overall mortality was 17.5%, with hydrops, endocardial fibroelastosis, and minority race/ethnicity identified as significant risk factors for death.
Why the study?
What are the risk factors associated with mortality and morbidity in offspring with anti-SSA/Ro-associated cardiac neonatal lupus?
Population
n=325 offspring exposed to maternal anti-SSA/Ro antibodies with cardiac neonatal lupus in a…
Design
Cohort
Follow-up
up to 10 years
Authors
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Mortality risk stratification by hydrops and endocardial fibroelastosis may inform counseling; leaves open prospective validation of targeted interventions.
Observational (n=325)
Yes
What are the risk factors associated with mortality and morbidity in offspring with anti-SSA/Ro-associated cardiac neonatal lupus?
Cardiac neonatal lupus carries a 17.5% mortality rate, with hydrops, endocardial fibroelastosis, and minority race/ethnicity being significant risk factors for death.
Izmirly et al. (2011) conducted an observational in Cardiac neonatal lupus (n=325). Cardiac neonatal lupus and associated risk factors was evaluated on Mortality. Among offspring with cardiac neonatal lupus, overall mortality was 17.5%, with hydrops, endocardial fibroelastosis, and minority race/ethnicity identified as significant risk factors for death.
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