Key result
A previous child with congenital heart block was associated with a 19% rate of heart block in subsequent pregnancies compared to 4% in those without (P=0.067).
Why the study?
Does serial fetal echocardiography predict or detect early signs of congenital heart block in fetuses of pregnant women with anti-SSA/Ro antibodies?
Cohort (n=127)
Does serial fetal echocardiography predict or detect early signs of congenital heart block in fetuses of pregnant women with anti-SSA/Ro antibodies?
Absolute Event Rate: 19% vs 4%
p-value: p=0.067
Serial fetal echocardiography revealed that PR interval prolongation is uncommon and does not reliably precede advanced congenital heart block in at-risk fetuses, though echodensities and tricuspid regurgitation may serve as early signs of injury.
No takes yet. Share an insight, caveat, or question.
May warrant closer surveillance in subsequent pregnancies after prior congenital heart block; leaves open whether risk stratification improves detection or outcomes.
Friedman et al. (2008) conducted a cohort in Fetuses at risk for congenital heart block (n=127). Previous child with congenital heart block vs. Mothers without a previous child with congenital heart block or rash was evaluated on Congenital heart block (p=0.067). A previous child with congenital heart block was associated with a 19% rate of heart block in subsequent pregnancies compared to 4% in those without (P=0.067).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: