Key result
A previous child with congenital heart block was associated with a 19% rate of heart block in subsequent pregnancies compared to 4% in those without (P=0.067).
Why the study?
Does serial fetal echocardiography predict or detect early signs of congenital heart block in fetuses of pregnant women with anti-SSA/Ro antibodies?
Population
127 pregnant women with anti-SSA/Ro antibodies (95 completed an evaluable course in 98 pregnancies)
Design
Cohort
Follow-up
Through gestation to birth
Authors
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May warrant closer surveillance in subsequent pregnancies after prior congenital heart block; leaves open whether risk stratification improves detection or outcomes.
Cohort (n=127)
Does serial fetal echocardiography predict or detect early signs of congenital heart block in fetuses of pregnant women with anti-SSA/Ro antibodies?
Absolute Event Rate: 19% vs 4%
p-value: p=0.067
Serial fetal echocardiography revealed that PR interval prolongation is uncommon and does not reliably precede advanced congenital heart block in at-risk fetuses, though echodensities and tricuspid regurgitation may serve as early signs of injury.
Friedman et al. (2008) conducted a cohort in Fetuses at risk for congenital heart block (n=127). Previous child with congenital heart block vs. Mothers without a previous child with congenital heart block or rash was evaluated on Congenital heart block (p=0.067). A previous child with congenital heart block was associated with a 19% rate of heart block in subsequent pregnancies compared to 4% in those without (P=0.067).
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