Key result
Fetuses of anti-Ro 52-kd-positive pregnant women frequently developed signs of first-degree AV block (8 of 24 fetuses), which spontaneously reverted in the majority of cases.
Why the study?
Does serial Doppler echocardiography detect early signs of congenital heart block in fetuses of pregnant women with anti-SSA/Ro 52-kd antibodies?
Population
24 pregnant women with anti-SSA/Ro 52-kd antibodies and 284 women with normal pregnancies as controls
Comparison
Serial Doppler echocardiography weekly between… vs Normal pregnancies (controls)
Design
Cohort
Follow-up
Weekly between 18 and 24 weeks of gestation, and at birth
Authors
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Supports serial echocardiography surveillance in anti-Ro pregnancies; leaves open whether early detection alters outcomes.
Cohort (n=308)
Does serial Doppler echocardiography detect early signs of congenital heart block in fetuses of pregnant women with anti-SSA/Ro 52-kd antibodies?
Serial Doppler echocardiography is useful for surveillance of high-risk pregnancies with anti-Ro 52-kd antibodies, as first-degree AV block frequently occurs but often reverts spontaneously.
Sonesson et al. (2004) conducted a cohort in Fetal heart block in anti-SSA/Ro 52-kd-positive pregnancies (n=308). Serial Doppler echocardiography vs. Normal pregnancies was evaluated on Signs of first-degree heart block. Fetuses of anti-Ro 52-kd-positive pregnant women frequently developed signs of first-degree AV block (8 of 24 fetuses), which spontaneously reverted in the majority of cases.
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