April 28, 2009AJP Endocrinology and Metabolism
Menstrual cycle alters sympathetic neural responses to orthostatic stress in young, eumenorrheic women
Key result
The midluteal phase of the menstrual cycle augmented total muscle sympathetic nerve activity responses to progressive orthostatic stress compared to the early follicular phase (P<0.04).
Why the study?
Does the midluteal phase of the menstrual cycle alter sympathetic neural responses to orthostatic stress compared to the early follicular phase in young, eumenorrheic women?
Population
13 healthy, eumenorrheic women (age 21 +/- 1 yr)
Comparison
Progressive lower body negative pressure during… vs Progressive lower body negative pressure during…
Design
Cohort
Authors
Discussion
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Member takes
Implication
Should not yet change clinical management of orthostatic stress; hypothesis-generating for menstrual phase effects on autonomic responses.
Study Design
Type
Observational (n=13)
Structured PICO
Does the midluteal phase of the menstrual cycle alter sympathetic neural responses to orthostatic stress compared to the early follicular phase in young, eumenorrheic women?
P
Population
13 healthy, eumenorrheic young women (mean age 21 years) evaluated during early follicular and midluteal phases of the menstrual cycle.
E
Exposure
Progressive lower body negative pressure (LBNP) (-5, -10, -15, -20, -30, and -40 mmHg; 3 min/stage) during the midluteal (ML) phase of the menstrual cycle
C
Comparator
Progressive lower body negative pressure (LBNP) during the early follicular (EF) phase of the menstrual cycle
O
Outcome
Sympathetic baroreflex sensitivity (BRS) and muscle sympathetic nerve activity (MSNA) responsessurrogate
Main Result
p-value: p=<0.04
The midluteal phase of the menstrual cycle augments muscle sympathetic nerve activity in response to orthostatic stress in healthy young women, independent of sympathetic baroreflex sensitivity.
Cite This Study
Carter et al. (2009) conducted an observational in Healthy, eumenorrheic women (n=13). Midluteal phase of the menstrual cycle vs. Early follicular phase was evaluated on Total muscle sympathetic nerve activity (MSNA) response during progressive lower body negative pressure (p=<0.04). The midluteal phase of the menstrual cycle augmented total muscle sympathetic nerve activity responses to progressive orthostatic stress compared to the early follicular phase (P<0.04).