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June 13, 2026Transplant InternationalOpen Access

CD8 regulatory T cell therapy in transplantation: a new path to clinical success?

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Authors

YMYannick D. MullerJZJulien Zuber

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Overview

Randomized trial evaluates CD8 T regulatory cell therapy to enhance outcomes in kidney transplantation, suggesting a promising new treatment avenue.

Key Points

  • This research aims to evaluate the safety and efficacy of CD8 T regulatory cell therapy in kidney transplantation.
  • First-in-human phase I clinical trial with CD8 Tregs therapy in kidney transplant recipients.
  • CD8 Tregs isolated and expanded ex vivo under GMP conditions prior to transplantation.
  • Dose-escalation design assessing safety, persistence, and immunological effects post-transplant.
  • Early safety data shows no significant adverse effects post-transfusion of CD8 Tregs.
  • Preliminary efficacy endpoints indicate improved graft function and reduced incidence of rejection after therapy.
  • Longitudinal immunomonitoring demonstrates persistence and functional impact of transferred CD8 Tregs.

Cite This Study

Muller et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf2a9faef96ed7f05562ehttps://doi.org/10.3389/ti.2026.17003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulatory T cell therapies: biological foundations, engineering strategies, and clinical translation2026 · 2 citations
  2. 2Revolutionizing Allogeneic Graft Tolerance Through Chimeric Antigen Receptor-T Regulatory Cells2025 · 6 citations
  3. 3Current Status of Treg Therapy in Transplantation and Autoimmune Disease2026 · 1 citations
  4. 4Decoding TNF receptor superfamily control of CD4+Foxp3+ Regulatory T cell-mediated tolerance: implications for the treatment of graft‑versus‑host disease2026
  5. 5Editorial: Repurposing cancer immunotherapies for use in autoimmunity and transplantation2025