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June 13, 2026Frontiers in EndocrinologyOpen Access

Changes in ambient environmental conditions correspond to variations in in vitro fertilization outcomes during the COVID-19 pandemic

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Authors

HKHeeyon KimHKHyun Jun KimSPSoyeong Park

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Overview

Randomized trial examines IVF success in relation to environmental conditions during COVID-19, indicating significant variations.

Key Points

  • This study aims to evaluate how IVF outcomes vary before, during, and after the COVID-19 pandemic and the role of environmental exposures in these changes.
  • Retrospective analysis of 1,871 IVF cycles for mature oocyte rate, 1,234 for fertilization rate, and 662 for clinical pregnancy conducted at a Seoul infertility center (2018–2024).
  • Assessment of environmental exposures (e.g., PM 2.5, NO 2) over different time frames (follicular-phase, 90-day, 365-day).
  • Statistical models (beta and logistic regression) were used to analyze data, adjusting for maternal and treatment variables.
  • Mature oocyte rates were significantly lower during (β = −0.32, p < 0.001) and post-COVID (β = −0.45, p < 0.001) compared to pre-COVID.
  • Post-COVID fertilization rates were significantly higher than pre-COVID (β = 0.22, p = 0.030), while during-COVID rates were not significantly different (p = 0.637).
  • No significant differences in pregnancy rates across the three periods (p = 0.346). Long-term environmental exposures significantly interacted with COVID periods affecting oocyte maturation rates (e.g., O 3: p = 0.002).

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf2a9faef96ed7f055647https://doi.org/10.3389/fendo.2026.1796050
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Also Consider

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  1. 1O-163 The effect of ambient exposure to air pollutants on live birth rates in frozen embryo transfer cycles2024
  2. 2Association between air pollutants exposure and in vitro fertilization outcomes: mediating role of remnant cholesterol and modifying effect of the ovarian sensitivity index2026
  3. 3O-075 Particulate matter (PM2.5 and PM10) exposure prior to oocyte collection is associated with decreased live birth rates in subsequent frozen embryo transfers2024 · 1 citations
  4. 4Mixed effects of ambient air pollutants on oocyte-related outcomes: A novel insight from women undergoing assisted reproductive technology2024 · 13 citations
  5. 5Synergistic effect of exposure to ambient ozone and fine particulate matter on embryonic developmental outcomes among an assisted reproductive population.2025