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June 13, 2026Frontiers in Cellular and Infection MicrobiologyOpen Access

Metabolic dysfunction-associated steatotic liver disease in chronic hepatitis B patients: risks of severe liver disease and cardiovascular disease

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Authors

NZNingxin ZhangZXZhongwei XuFLFei Lin

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Overview

Randomized trial shows the association between metabolic dysfunction and liver and cardiovascular risks in hepatitis B patients, indicating significant health implications.

Key Points

  • The study aims to evaluate how Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) affects the risk of severe liver disease and cardiovascular disease in Chronic Hepatitis B patients.
  • Patients with Chronic Hepatitis B were recruited from 2012 to 2022 using an electronic medical record system.
  • Participants were categorized into CHB-no MASLD and CHB-MASLD groups, with follow-up lasting until January 2024.
  • Cumulative incidence and associated risk factors were analyzed for both groups.
  • MASLD was associated with a 39% lower risk of severe liver disease (aHR=0.61, 95% CI 0.49-0.76, p<0.001).
  • For cirrhosis: aHR=0.61, 95% CI 0.45-0.82, p=0.001, and for hepatocellular carcinoma: aHR=0.57, 95% CI 0.41-0.80, p=0.001.
  • Conversely, MASLD presented a higher CVD risk (aHR=1.16, 95% CI 0.96-1.41, p=0.130), especially concerning coronary artery disease (aHR=1.91, 95% CI 1.34-2.74, p<0.001).

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf2a9faef96ed7f0557cahttps://doi.org/10.3389/fcimb.2026.1806927
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