What question did this study set out to answer?

To evaluate the clinical characteristics and patient-reported outcomes of HBV and HCV patients with and without metabolic dysfunction-associated steatotic liver disease (MASLD).

July 10, 2026Journal of Gastroenterology and Hepatology

Chronic Viral Hepatitis With MASLD: Implications for Clinical and Patient‐Reported Outcomes

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Authors

GPGeorge PapatheodoridisNational and Kapodistrian University of Athens MBMaria ButiVall d'Hebron Hospital Universitari YYYusuf YılmazRecep Tayyip Erdoğan University

Discussion

Member takes

Implication

Cross-sectional study evaluates clinical characteristics and patient-reported outcomes in viral hepatitis patients with MASLD, suggesting the need for metabolic assessment.

Key Points

To evaluate the clinical characteristics and patient-reported outcomes of HBV and HCV patients with and without metabolic dysfunction-associated steatotic liver disease (MASLD).
Cross-sectional analysis of clinical and PRO data from Global Liver Registry.
Inclusion of HBV and HCV patients with a defined MASLD using Hepatic Steatosis Index.
Assessment of fatigue and quality of life using specific questionnaires (FACIT-F, CLDQ, WPAI).
Among 4649 subjects, nearly 50% of HBV and HCV patients had MASLD.
Patients with MASLD showed significantly lower PRO scores, particularly in fatigue and overall well-being (p < 0.01).
MASLD remained independently associated with lower quality of life scores in multivariate analysis (p < 0.05).

Cite This Study

Papatheodoridis et al. (2026) studied this question.

synapsesocial.com/papers/6a508c2d6eeac72a437a05f1 https://doi.org/10.1111/jgh.70533

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July 10, 2026Journal of Gastroenterology and Hepatology

Chronic Viral Hepatitis With MASLD: Implications for Clinical and Patient‐Reported Outcomes

View Full Paper

Ask AI

Bookmark

Authors

GPGeorge PapatheodoridisNational and Kapodistrian University of Athens MBMaria ButiVall d'Hebron Hospital Universitari YYYusuf YılmazRecep Tayyip Erdoğan University

Discussion

Member takes

Implication

Cross-sectional study evaluates clinical characteristics and patient-reported outcomes in viral hepatitis patients with MASLD, suggesting the need for metabolic assessment.

Key Points

To evaluate the clinical characteristics and patient-reported outcomes of HBV and HCV patients with and without metabolic dysfunction-associated steatotic liver disease (MASLD).
Cross-sectional analysis of clinical and PRO data from Global Liver Registry.
Inclusion of HBV and HCV patients with a defined MASLD using Hepatic Steatosis Index.
Assessment of fatigue and quality of life using specific questionnaires (FACIT-F, CLDQ, WPAI).
Among 4649 subjects, nearly 50% of HBV and HCV patients had MASLD.
Patients with MASLD showed significantly lower PRO scores, particularly in fatigue and overall well-being (p < 0.01).
MASLD remained independently associated with lower quality of life scores in multivariate analysis (p < 0.05).

Cite This Study

Papatheodoridis et al. (2026) studied this question.

synapsesocial.com/papers/6a508c2d6eeac72a437a05f1 https://doi.org/10.1111/jgh.70533

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