An Exploration of Real-world Serum Neurofilament Light Chain Measurement and Rate of ALSFRS-R Decline (P10-9.004)

Cate Ledoux; Micah Hamilton; Cassandra Holmes; Nicholas Streicher; Shakti Nayar

doi:10.1212/wnl.0000000000217648

June 9, 2026Neurology

An Exploration of Real-world Serum Neurofilament Light Chain Measurement and Rate of ALSFRS-R Decline (P10-9.004)

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Key Points

This research evaluates the relationship between serum neurofilament light chain levels and ALS progression as measured by the ALSFRS-R.
Utilized serum samples to measure neurofilament light chain levels.
Assessed changes in the Revised ALS Functional Rating Scale (ALSFRS-R) questionnaire.
Conducted analysis in a clinical setting to evaluate associations.
Significant association found between increasing serum NfL levels and decline in ALSFRS-R scores.
Indicates that higher NfL levels correlate with faster ALS progression.

Implication

Measures serum NfL levels and ALSFRS-R decline in patients, suggesting potential biomarkers for ALS progression.

Abstract

Our aim was to evaluate whether measures used to assess ALS progression in the clinical setting, specifically changes in the Revised ALS Functional Rating Scale (ALSFRS-R) questionnaire, are meaningfully associated with serum neurofilament light chain (NfL) levels measured by a commercial laboratory.

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Cite This Study

Ledoux et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf300faef96ed7f05596d https://doi.org/10.1212/wnl.0000000000217648

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An Exploration of Real-world Serum Neurofilament Light Chain Measurement and Rate of ALSFRS-R Decline (P10-9.004)

Key Points

Implication

Abstract

Discussion

Cite This Study

An Exploration of Real-world Serum Neurofilament Light Chain Measurement and Rate of ALSFRS-R Decline (P10-9.004)

Key Points

Implication

Abstract

Discussion

Cite This Study

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