What question did this study set out to answer?

This study aims to investigate the distribution of lipoprotein(a) levels in children with elevated LDL cholesterol, particularly focusing on its relation to familial hypercholesterolemia.

June 13, 2026Journal of Atherosclerosis and ThrombosisOpen Access

Distribution of Lipoprotein(a) Levels Among Children with Elevated Low-Density Lipoprotein Cholesterol Identified Through Universal Pediatric Lipid Screening

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Authors

RTRyosuke TaniKagawa University KMKeiji MatsunagaKagawa University KTKeita TanimotoKagawa University

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Overview

Randomized trial clarifies Lp(a) distribution in children with high LDL cholesterol, suggesting implications for cardiovascular risk management.

Key Points

This study aims to investigate the distribution of lipoprotein(a) levels in children with elevated LDL cholesterol, particularly focusing on its relation to familial hypercholesterolemia.
Analyzed 97 children with LDL cholesterol ≥ 140 mg/dL suspected of familial hypercholesterolemia.
Lp(a) levels were measured using the Lp(a) Latex 'DAIICHI' assay and converted to molar units.
Compared clinical and lipid parameters against Lp(a) levels and presence of pathogenic FH variants.
Right-skewed distribution of Lp(a), with a median of 57.6 nmol/L; 21.6% of children had levels ≥ 105 nmol/L.
Pathogenic FH variants found in 44 children; no significant clinical or lipid parameter differences based on Lp(a) levels or variant presence (P = 0.672).
20% of children had elevated Lp(a) levels regardless of pathogenic FH variant status, signaling a need for early lipid management.

Cite This Study

Tani et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf32afaef96ed7f055b2c https://doi.org/10.5551/jat.66114

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June 13, 2026Journal of Atherosclerosis and ThrombosisOpen Access

Distribution of Lipoprotein(a) Levels Among Children with Elevated Low-Density Lipoprotein Cholesterol Identified Through Universal Pediatric Lipid Screening

View Full Paper

Ask AI

Bookmark

Authors

RTRyosuke TaniKagawa University KMKeiji MatsunagaKagawa University KTKeita TanimotoKagawa University

Discussion

Member takes

Overview

Randomized trial clarifies Lp(a) distribution in children with high LDL cholesterol, suggesting implications for cardiovascular risk management.

Key Points

This study aims to investigate the distribution of lipoprotein(a) levels in children with elevated LDL cholesterol, particularly focusing on its relation to familial hypercholesterolemia.
Analyzed 97 children with LDL cholesterol ≥ 140 mg/dL suspected of familial hypercholesterolemia.
Lp(a) levels were measured using the Lp(a) Latex 'DAIICHI' assay and converted to molar units.
Compared clinical and lipid parameters against Lp(a) levels and presence of pathogenic FH variants.
Right-skewed distribution of Lp(a), with a median of 57.6 nmol/L; 21.6% of children had levels ≥ 105 nmol/L.
Pathogenic FH variants found in 44 children; no significant clinical or lipid parameter differences based on Lp(a) levels or variant presence (P = 0.672).
20% of children had elevated Lp(a) levels regardless of pathogenic FH variant status, signaling a need for early lipid management.

Cite This Study

Tani et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf32afaef96ed7f055b2c https://doi.org/10.5551/jat.66114

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