What question did this study set out to answer?

This study aims to assess the role of lipoprotein(a) in contributing to low-density lipoprotein cholesterol levels in children with hypercholesterolemia.

February 26, 2026European Journal of Preventive CardiologyOpen Access

Lipoprotein(a) levels in children with hypercholesterolemia

Q: What is the clinical evidence from this study?

Study design: Observational. Population: hypercholesterolemia (n=1418). Intervention: Possible familial hypercholesterolemia vs. Definite familial hypercholesterolemia. Primary outcome: Elevated Lp(a) levels (>30 mg/dL) (p=0.003).

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Key result

Elevated Lp(a) is linked to ~39% higher prevalence in possible vs definite pediatric FH.

P=0.003
n=1,418

Population

1,418 children with hypercholesterolemia, identified by universal or cascade familial hypercholesterolemia…

Design

Cross-sectional

Authors

MMMatej MlinarićUniversity of Ljubljana BKBarbara Čugalj KernUniversity of Ljubljana ATAna Drole Torkar

Discussion

Member takes

Implication

Elevated Lp(a) is common in children with familial and polygenic hypercholesterolemia and contributes significantly to LDL-C levels, highlighting the need for early targeted evaluation.

Key Points

This study aims to assess the role of lipoprotein(a) in contributing to low-density lipoprotein cholesterol levels in children with hypercholesterolemia.
Included 1,418 children with hypercholesterolemia identified through screening
Categorized participants into definite FH, possible FH, and definite non-FH groups
Measured Lp(a) levels and their association with LDL-C and Apolipoprotein B
25.1% of definite FH and 34.9% of possible FH children had elevated Lp(a) levels
In definite FH, Lp(a) levels accounted for 32.7% of LDL-C and 18.6% of Apolipoprotein B levels
Elevated LDL-C persisted in 88.4% of definite FH and 30.4% of possible FH children even after adjusting for Lp(a)

Study Design

Type

Observational (n=1,418)

Structured PICO

Population

1,418 children (median age 6.34 years) with hypercholesterolemia identified by universal or cascade screening in Slovenia.

Outcome

Role and impact of Lp(a) on LDL-C levelssurrogate

Main Result

Absolute Event Rate: 34.9% vs 25.1%

p-value: p=0.003

Elevated Lp(a) is common in children with familial and polygenic hypercholesterolemia and contributes significantly to LDL-C levels, highlighting the need for early targeted evaluation.

Cite This Study

Mlinarić et al. (2026) conducted an observational in hypercholesterolemia (n=1,418). Possible familial hypercholesterolemia vs. Definite familial hypercholesterolemia was evaluated on Elevated Lp(a) levels (>30 mg/dL) (p=0.003). Elevated Lp(a) levels (>30 mg/dL) were significantly more prevalent in children with possible familial hypercholesterolemia compared to those with definite FH (34.9% vs 25.1%, p=0.003).

synapsesocial.com/papers/699fe35995ddcd3a253e7215 https://doi.org/10.1093/eurjpc/zwag126

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Implication

Elevated Lp(a) is common in children with familial and polygenic hypercholesterolemia and contributes significantly to LDL-C levels, highlighting the need for early targeted evaluation.

Lipoprotein(a) levels in children with hypercholesterolemia

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Lipoprotein(a) levels in children with hypercholesterolemia

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider