Investigating Brain Glutathione Levels in Primary Mitochondrial Disease Using Edited MR Spectroscopy (P9-7.003)

Sonal Sharma; Albert Wu; Sara Nguyen; Reza Abdavies; Zarazuela Zolkipli-Cunningham; Muhammad Saleh

doi:10.1212/wnl.0000000000217587

June 9, 2026Neurology

Investigating Brain Glutathione Levels in Primary Mitochondrial Disease Using Edited MR Spectroscopy (P9-7.003)

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Key Points

This research aims to evaluate brain glutathione levels in patients with primary mitochondrial disease using magnetic resonance spectroscopy.
Novel use of edited magnetic resonance spectroscopy for glutathione level assessment.
Comparison made between patients with primary mitochondrial disease and healthy controls.
Significantly lower glutathione levels observed in primary mitochondrial disease patients compared to healthy controls.

Implication

Investigates glutathione levels in primary mitochondrial disease, suggesting metabolic differences from healthy controls.

Abstract

Novel evaluation of brain glutathione (GSH) levels in Primary Mitochondrial Disease (PMD) patients by edited Magnetic Resonance Spectroscopy (MRS) compared to healthy controls.

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Cite This Study

Sharma et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf32afaef96ed7f055ba1 https://doi.org/10.1212/wnl.0000000000217587

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Investigating Brain Glutathione Levels in Primary Mitochondrial Disease Using Edited MR Spectroscopy (P9-7.003)

Key Points

Implication

Abstract

Discussion

Cite This Study

Investigating Brain Glutathione Levels in Primary Mitochondrial Disease Using Edited MR Spectroscopy (P9-7.003)

Key Points

Implication

Abstract

Discussion

Cite This Study

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