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June 9, 2026Neurology

Clinical Significance of Interleukin-6 in Multiple Sclerosis: A Systematic Review and Meta-analysis (P6-18.002)

Anapaula Cabanillas Seminario Gerardo Luna-Peralta Leonardo Di Cosmo Kevin Cervera Alvaro Milla-Martinez Bryan Rudas Sulca Fernando Reyes DIEGO LOPEZ Angela Ariana Milagros Salvador Palma Angela Remuzgo-Cabezas Danielle Kei Pua

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Key Points

This research aims to evaluate the importance of interleukin-6 (IL-6) in multiple sclerosis (MS) by consolidating existing evidence.
Conducted a systematic review and meta-analysis of studies on IL-6 in MS.
Included various studies measuring IL-6 levels and clinical outcomes in MS patients.
Analyses focused on the relationship between IL-6 and disease progression.
Found elevated IL-6 levels correlate with increased disease severity in MS.
IL-6 was associated with poor clinical outcomes, such as disability progression.
The review suggested IL-6 could serve as a potential therapeutic target in MS.

Implication

Systematic review summarizes the role of interleukin-6 in multiple sclerosis, indicating its importance in inflammation.

Abstract

To summarize the current evidence on the clinical significance of interleukin (IL)-6 in multiple sclerosis (MS).

Discussion

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Cite This Study

Seminario et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf34dfaef96ed7f055c69 https://doi.org/10.1212/wnl.0000000000217782

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