Cannabidiol Efficacy in Patients with Lennox-Gastaut Syndrome with Developmental and Epileptic Encephalopathy-associated Genetic Variants: A Subgroup Analysis (P10-10.008)

Elizabeth A. Thiele; Michael Boffa; Daniel Checketts; Farhad Sahebkar

doi:10.1212/wnl.0000000000215584

June 9, 2026Neurology

Cannabidiol Efficacy in Patients with Lennox-Gastaut Syndrome with Developmental and Epileptic Encephalopathy-associated Genetic Variants: A Subgroup Analysis (P10-10.008)

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Key Points

The research aims to assess the effectiveness of cannabidiol in patients with both Lennox-Gastaut syndrome and developmental epileptic encephalopathies.
Subgroup analysis of participants from a randomized clinical trial.
Participants included those with genetic developmental and epileptic encephalopathies alongside Lennox-Gastaut syndrome.
Cannabidiol used was a highly purified oral solution (100 mg/mL).
Efficacy results suggested improvements in seizure control among participants with genetic variants.
The findings imply potential specific benefits of cannabidiol for this subgroup.

Implication

Randomized trial evaluates cannabidiol's efficacy in Lennox-Gastaut syndrome patients with genetic variants, suggesting potential benefits.

Abstract

To evaluate the efficacy of highly purified cannabidiol (CBD; Epidiolex® [US]/Epidyolex® [EU], 100 mg/mL oral solution) in a subgroup of randomized clinical trial (RCT) participants with genetic developmental and epileptic encephalopathies (DEEs) in addition to Lennox-Gastaut syndrome (LGS).

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Cite This Study

Thiele et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf34dfaef96ed7f055cae https://doi.org/10.1212/wnl.0000000000215584

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Cannabidiol Efficacy in Patients with Lennox-Gastaut Syndrome with Developmental and Epileptic Encephalopathy-associated Genetic Variants: A Subgroup Analysis (P10-10.008)

Key Points

Implication

Abstract

Discussion

Cite This Study

Cannabidiol Efficacy in Patients with Lennox-Gastaut Syndrome with Developmental and Epileptic Encephalopathy-associated Genetic Variants: A Subgroup Analysis (P10-10.008)

Key Points

Implication

Abstract

Discussion

Cite This Study

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