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June 13, 2026Biomedicine & PharmacotherapyOpen Access

Alogliptin attenuates diabetes-associated cognitive impairment in rats via HMGB1/RAGE/TLR4-NFκB pathway modulation

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Authors

RARaneem M. AtaEEEl-Sayed E. El-AwadyRHReem M. Hazem

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Overview

Randomized trial explores how alogliptin improves memory dysfunction in rats with diabetes, suggesting therapeutic potential.

Key Points

  • This research investigates the effects of alogliptin on cognitive impairments caused by diabetes in rats. It aims to understand the underlying mechanisms through which alogliptin mitigates neuroinflammation.
  • Induced Type 2 Diabetes Mellitus (T2DM) in rats using a high-fat diet followed by streptozotocin injection.
  • Administered alogliptin at dosages of 20 mg/kg/day and 40 mg/kg/day for 28 days.
  • Evaluated memory function using the Morris Water Maze and Y-maze tests, followed by biochemical and immunohistochemical analyses of brain tissue.
  • Alogliptin significantly improved memory function in the T2DM rats assessed by Morris Water Maze and Y-maze tests.
  • Reduced levels of neuroinflammatory markers HMGB1, RAGE, and TLR4/NF-κB signaling were observed, leading to decreased TNF-α and IL-1β cytokines.
  • Enhanced antioxidant activity was noted with increased SOD, CAT, and GSH levels and decreased MDA levels.

Cite This Study

Ata et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf34dfaef96ed7f055cc2https://doi.org/10.1016/j.biopha.2026.119634
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