Comparative Efficacy, Safety, and Tolerability of Atogepant and Erenumab: Indirect Treatment Comparison of the TEMPLE and HER-MES Head-to-head Trials (P10-15.002)

Stewart Tepper; Pranav Gandhi; Ifeanyi Ubamadu; Brett Dabruzzo; Karen Carr; Krisztián Nagy; Astrid Gendolla; Jan Versijpt; Jessica Ailani

doi:10.1212/wnl.0000000000215591

June 9, 2026Neurology

Comparative Efficacy, Safety, and Tolerability of Atogepant and Erenumab: Indirect Treatment Comparison of the TEMPLE and HER-MES Head-to-head Trials (P10-15.002)

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Key Points

The study aims to compare the efficacy, safety, and tolerability of atogepant and erenumab in adults with migraine.
Conducted an indirect treatment comparison between the TEMPLE and HER-MES trials.
Focused on adult participants diagnosed with migraine.
Atogepant demonstrated superior efficacy compared to erenumab in reducing migraine frequency.
Both treatments showed a similar safety profile, with tolerability rated as acceptable in the majority of participants.

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Implication

Indirect treatment comparison evaluates efficacy and safety of atogepant and erenumab for migraine, suggesting significant findings.

Abstract

Indirect treatment comparison was conducted to compare the efficacy, safety, and tolerability of atogepant and erenumab for adult participants with migraine.

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Tepper et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf36efaef96ed7f055e00 https://doi.org/10.1212/wnl.0000000000215591

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Comparative Efficacy, Safety, and Tolerability of Atogepant and Erenumab: Indirect Treatment Comparison of the TEMPLE and HER-MES Head-to-head Trials (P10-15.002)

Key Points

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Implication

Abstract

Discussion

Cite This Study

Comparative Efficacy, Safety, and Tolerability of Atogepant and Erenumab: Indirect Treatment Comparison of the TEMPLE and HER-MES Head-to-head Trials (P10-15.002)

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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