Tolerability, Safety, and Efficacy of Atogepant Versus Topiramate in Participants Requiring Preventive Treatment for Migraine: Results from the Head-to-head TEMPLE Trial (P10-15.009)

Uwe Reuter; Annelies Van Dycke; Stewart Tepper; Mark Kristof Farkas; Giovanna Forero; Lei Luo; Hua Guo; eric cohen; Krisztian Nagy

doi:10.1212/wnl.0000000000215537

June 9, 2026Neurology

Tolerability, Safety, and Efficacy of Atogepant Versus Topiramate in Participants Requiring Preventive Treatment for Migraine: Results from the Head-to-head TEMPLE Trial (P10-15.009)

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Key Points

To evaluate the tolerability, safety, and efficacy of atogepant compared to topiramate in migraine prevention.
Participants received either atogepant or topiramate for migraine prevention.
Study assessed tolerability and safety outcomes alongside efficacy measures.
Atogepant demonstrated superior tolerability compared to topiramate.
Efficacy outcomes favored atogepant in reducing migraine frequency.
Safety profiles were analyzed, indicating fewer adverse effects with atogepant.

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Implication

Compares efficacy and safety of atogepant with topiramate in migraine prevention, suggesting atogepant may be a favorable alternative.

Abstract

Compare the tolerability, safety, and efficacy between atogepant, an oral calcitonin gene-related peptide receptor antagonist, and topiramate in participants requiring preventive migraine treatment.

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Reuter et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f0561d6 https://doi.org/10.1212/wnl.0000000000215537

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Tolerability, Safety, and Efficacy of Atogepant Versus Topiramate in Participants Requiring Preventive Treatment for Migraine: Results from the Head-to-head TEMPLE Trial (P10-15.009)

Key Points

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Implication

Abstract

Discussion

Cite This Study

Tolerability, Safety, and Efficacy of Atogepant Versus Topiramate in Participants Requiring Preventive Treatment for Migraine: Results from the Head-to-head TEMPLE Trial (P10-15.009)

Key Points

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Implication

Abstract

Discussion

Cite This Study

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