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June 9, 2026Neurology

LGI1 Encephalitis Masquerading as Creutzfeldt-Jakob Disease – A Diagnostic Challenge: Case Report (P11-1.010)

Rohan Joshi Prasanna Venkatesan Eswaradass Elana Goldenberg Yunxia Wang

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Key Points

This case aims to highlight the diagnostic challenges when LGI1 encephalitis presents with symptoms similar to Creutzfeldt-Jakob Disease (CJD).
Detailed clinical assessment of the patient who met probable CJD criteria.
Diagnostic testing included neurological evaluations and biomarkers to differentiate between conditions.
The case ultimately revealed a diagnosis of LGI1 encephalitis instead of CJD.
Misdiagnosis led to delays in appropriate treatment, emphasizing the need for thorough diagnostic processes.

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Implication

Case report highlights the diagnostic complexities of LGI1 encephalitis resembling CJD symptoms.

Abstract

To describe a diagnostically challenging case of LGI1 encephalitis in a patient who initially met “probable CJD” criteria.

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Cite This Study

Joshi et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf36efaef96ed7f055e6a https://doi.org/10.1212/wnl.0000000000213234

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