What question did this study set out to answer?

This research aims to evaluate the enhanced therapeutic potential of pentanoylated ferulic acid in ameliorating psoriasis through specific molecular pathways.

June 13, 2026Biomedicine & PharmacotherapyOpen Access

Enhanced efficacy of methyl ferulate upon pentanoylation in ameliorating psoriasis via Nrf2/NF-κB pathway regulation and HDACs downregulation

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Authors

CLChenxi Li YYYuanyuan Yang AZAo Zhang

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Overview

Randomized trial demonstrates enhanced efficacy of pentanoylated methyl ferulate in psoriasis, suggesting a novel therapeutic strategy.

Key Points

This research aims to evaluate the enhanced therapeutic potential of pentanoylated ferulic acid in ameliorating psoriasis through specific molecular pathways.
Utilized an imiquimod-induced psoriasis-like mouse model
Compared pentanoylated ferulic acid methyl ester with parent compounds
Analyzed effects of treatment on HDAC expression and Nrf2/NF-kB pathway activities.
PentFAMe exhibited superior anti-inflammatory effects with significantly lower proinflammatory cytokines.
Inhibition of HDAC3/6 resulted in restored H3K27 and NF-kB p65 acetylation levels.
PentFAMe activated Nrf2 pathway more effectively than ferulic acid, leading to reduced NF-kB phosphorylation.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf393faef96ed7f0560c3 https://doi.org/10.1016/j.biopha.2026.119638

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June 13, 2026Biomedicine & PharmacotherapyOpen Access

Enhanced efficacy of methyl ferulate upon pentanoylation in ameliorating psoriasis via Nrf2/NF-κB pathway regulation and HDACs downregulation

View Full Paper

Ask AI

Bookmark

Authors

CLChenxi Li YYYuanyuan Yang AZAo Zhang

Discussion

Member takes

Overview

Randomized trial demonstrates enhanced efficacy of pentanoylated methyl ferulate in psoriasis, suggesting a novel therapeutic strategy.

Key Points

This research aims to evaluate the enhanced therapeutic potential of pentanoylated ferulic acid in ameliorating psoriasis through specific molecular pathways.
Utilized an imiquimod-induced psoriasis-like mouse model
Compared pentanoylated ferulic acid methyl ester with parent compounds
Analyzed effects of treatment on HDAC expression and Nrf2/NF-kB pathway activities.
PentFAMe exhibited superior anti-inflammatory effects with significantly lower proinflammatory cytokines.
Inhibition of HDAC3/6 resulted in restored H3K27 and NF-kB p65 acetylation levels.
PentFAMe activated Nrf2 pathway more effectively than ferulic acid, leading to reduced NF-kB phosphorylation.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf393faef96ed7f0560c3 https://doi.org/10.1016/j.biopha.2026.119638

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