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September 1, 1999British Journal of Dermatology

Treatment of severe psoriasis with fumaric acid esters: scientific background and guidelines for therapeutic use

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Authors

MMrowietzCChristophersAAAltmeyer For The German Fumaric Aci

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Overview

Consensus review demonstrates the efficacy and safety of fumaric acid esters in severe psoriasis vulgaris, highlighting immune shifts from Th1 to Th2 pathways to guide clinical practice.

Key Points

  • To review the experimental mechanisms and clinical trial evidence for fumaric acid esters in severe psoriasis vulgaris and establish expert consensus treatment guidelines.
  • Synthesized molecular and cellular evidence regarding T-cell polarization and keratinocyte dynamics under fumaric acid ester exposure.
  • Evaluated multicentre trial data detailing clinical therapeutic efficacy and the spectrum of adverse effects.
  • Convened an expert consensus meeting to establish standardized clinical practice recommendations for dermatologists.
  • Multicentre clinical trials demonstrate that fumaric acid esters provide significant therapeutic efficacy in severe psoriasis vulgaris with an established, predictable adverse-effect profile.
  • Experimental findings reveal that fumaric acid esters drive an immunomodulatory shift from a Th1-dominated T-cell response to a Th2-like pattern while simultaneously suppressing keratinocyte proliferation.

Cite This Study

Mrowietz et al. (1999) studied this question.

synapsesocial.com/papers/69df0867d85e58e37b7a0dcdhttps://doi.org/10.1046/j.1365-2133.1999.03034.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1AN INTENSIVE REVIEW ON THE MANAGEMENT OF PSORIASIS: FUMARIC ACID ESTERS ANALOGS2024
  2. 2Coxsackievirus A6 infection presenting with different clinical phenotypes of hand-foot-and-mouth disease in two brothers at the same time2020 · 1 citations
  3. 3Discontinuation of Fumaric Acid Esters is Affected by Depressive Symptomatology: A Retrospective Analysis2024
  4. 4Enhanced efficacy of methyl ferulate upon pentanoylation in ameliorating psoriasis via Nrf2/NF-κB pathway regulation and HDACs downregulation2026
  5. 5Fumaric Acid Esters as Modulators of Ocular Inflammation and Angiogenesis2026