Key result
Two brothers infected with Coxsackievirus A6 simultaneously presented with different clinical phenotypes of hand-foot-and-mouth disease, suggesting atopic dermatitis as a risk factor for the atypical form.
Why the study?
Fumaric acid esters are the most widely used oral systemic treatment for moderate-to-severe psoriasis in Germany, but little is known about the demographics of patients receiving them.
Comparison
Fumaric acid esters vs methotrexate
Design
National patient registry study
Authors
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FAE initiators in German registry differ demographically from MTX users; leaves open whether these profiles affect comparative outcomes.
Case Report (n=2)
No
Atopic dermatitis may be a risk factor for atypical hand-foot-and-mouth disease caused by Coxsackievirus A6 in children.
Takenaka et al. (2020) conducted a case report in Hand-foot-and-mouth disease (n=2). Coxsackievirus A6 infection was evaluated on Clinical phenotype of HFMD. Two brothers infected with Coxsackievirus A6 simultaneously presented with different clinical phenotypes of hand-foot-and-mouth disease, suggesting atopic dermatitis as a risk factor for the atypical form.
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