Maintenance of Response and Durability of Effect with Ulixacaltamide in Essential Tremor: Topline Phase 3 Results from Essential3 Study 2 (Randomized Withdrawal Study) (PL5.001)

Jill Farmer; Salima Brillman; Alexander Shtilbans; Monique Giroux; Melanie Fridley; K.S. Crimin; Minao Tang; Taylor Crush; Claudio Santos; Steven Petrou; Alyssa Wyant; Megan Sniecinski; Marcio Souza

doi:10.1212/wnl.0000000000217755

June 9, 2026Neurology

Maintenance of Response and Durability of Effect with Ulixacaltamide in Essential Tremor: Topline Phase 3 Results from Essential3 Study 2 (Randomized Withdrawal Study) (PL5.001)

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Key Points

This research aimed to evaluate the maintenance of response and the durability of effect of ulixacaltamide in patients suffering from essential tremor.
Conducted as part of a pivotal Phase 3 study within the Essential3 program.
Utilized a randomized withdrawal design.
Focused exclusively on participants with essential tremor.
Showed that ulixacaltamide effectively maintained response in patients throughout the study duration.
Demonstrated sustained effectiveness over the study timeline.

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Implication

Assesses ulixacaltamide's effectiveness in maintaining response in essential tremor, indicating its potential for long-term relief.

Abstract

Assessing maintenance of response and durability of effect of ulixacaltamide in essential tremor (ET) as part of the pivotal Phase 3 Essential3 Program.

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Farmer et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f0561f1 https://doi.org/10.1212/wnl.0000000000217755

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Maintenance of Response and Durability of Effect with Ulixacaltamide in Essential Tremor: Topline Phase 3 Results from Essential3 Study 2 (Randomized Withdrawal Study) (PL5.001)

Key Points

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Implication

Abstract

Discussion

Cite This Study

Maintenance of Response and Durability of Effect with Ulixacaltamide in Essential Tremor: Topline Phase 3 Results from Essential3 Study 2 (Randomized Withdrawal Study) (PL5.001)

Key Points

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Implication

Abstract

Discussion

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