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June 9, 2026Neurology

Combined Efficacy and Safety of Ulixacaltamide in Essential Tremor: Topline Results from the Phase 3 Essential3 Program (P5-17.003)

Alexander Shtilbans Jill Farmer Salima Brillman Monique Giroux Melanie Fridley K.S. Crimin Minao Tang Taylor Crush Claudio Santos Steven Petrou Alyssa Wyant Megan Sniecinski Marcio Souza

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Key Points

This research aims to assess how effective and safe ulixacaltamide is for treating essential tremor in adults.
Phase 3 clinical trial design.
Participants included adults diagnosed with essential tremor.
Efficacy and safety outcomes were evaluated.
Ulixacaltamide demonstrated significant efficacy in reducing tremor severity.
Safety profile was acceptable with manageable side effects.

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Implication

Evaluates efficacy and safety of ulixacaltamide in adults with essential tremor, suggesting potential treatment benefits.

Abstract

Evaluating the overall efficacy and safety of ulixacaltamide in adults with essential tremor (ET) across the pivotal Phase 3 Essential3 Program.

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Cite This Study

Shtilbans et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf300faef96ed7f055961 https://doi.org/10.1212/wnl.0000000000217776

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Synapse has enriched 10 related papers. Consider them for comparative context:

1Maintenance of Response and Durability of Effect with Ulixacaltamide in Essential Tremor: Topline Phase 3 Results from Essential3 Study 2 (Randomized Withdrawal Study) (PL5.001)Late-Phase Clinical Trial · 2026
2An Innovative Multi-study Phase 3 Program to Evaluate the Efficacy and Safety of Ulixacaltamide: The Future of Clinical Trial Design in Essential Tremor (P3-3.003)2024 · 3 citations
3Assessing Clinically Meaningful Improvement Associated with Ulixacaltamide Treatment in Adults with Essential Tremor on Concomitant Propranolol: Findings from Essential1 (S30.010)2024 · 1 citations
4IncobotulinumtoxinA for Upper Limb Essential Tremor: A Randomized, Double-Blind, Placebo-Controlled TrialBlinded Clinical Trial · 2026
5Safety and Effectiveness of Unilateral Transcranial Magnetic Resonance-Guided Focused Ultrasound in Essential Tremor: One-Year Single-Center Real-World Results2025
6Focused Ultrasound for Essential Tremor in Denmark: Results After 1 Year of Follow‐UpCohort Study · 2026
7Staged Bilateral MR-guided Focused Ultrasound in Essential Tremor: Safety, Efficacy, and Rising Adoption of Second-side Treatment (P5-17.001)Original Research · 2026
8Pilot efficacy and tolerability: A randomized, placebo‐controlled trial of levetiracetam for essential tremorRCT · 2004 · 50 citations
9Evaluation of Submandibular Gland Biopsies With Real-Time Quaking-Induced Conversion in Clinical Parkinson DiseaseNeurology · 2026
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