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June 13, 2026Neurology

Staged Bilateral MR-guided Focused Ultrasound in Essential Tremor: Safety, Efficacy, and Rising Adoption of Second-side Treatment (P5-17.001)

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Authors

IPIan PyleLKLindsay KnightRMRegina Martuscello

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Overview

Randomized trial evaluates efficacy and safety of MR-guided focused ultrasound thalamotomy in essential tremor, highlighting second-side treatment landscape after FDA approval.

Key Points

  • The aim is to assess the effectiveness and safety of staged bilateral MR-guided focused ultrasound thalamotomy for essential tremor patients who do not respond to medication.
  • Executed staged bilateral MR-guided focused ultrasound thalamotomy in medication-refractory essential tremor patients.
  • Evaluated safety and efficacy outcomes post-treatment.
  • Analyzed the uptake of second-side treatments following FDA approval.
  • Demonstrated significant improvement in tremor control post-treatment.
  • Safety profile was acceptable, with minimal adverse effects reported.
  • Increased adoption of second-side treatments noted since FDA approval.

Cite This Study

Pyle et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3d6faef96ed7f0563adhttps://doi.org/10.1212/wnl.0000000000217463
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Staged Bilateral Magnetic Resonance‐Guided Focused Ultrasound Thalamotomy for Essential Tremor: Prospective Single‐Centre Cohort and Systematic Review With Meta‐Analysis2026 · 7 citations
  2. 2Systematic Literature Review on Staged-bilateral MRI-guided High-intensity Focused Ultrasound for Treatment of Essential Tremor (P2-17.002)2026
  3. 3Real‐World Evaluation of Bilateral Magnetic Resonance–Guided Focused Ultrasound Thalamotomy in Essential Tremor2026 · 1 citations
  4. 4Real-world Evaluation of Staged-bilateral Focused Ultrasound Thalamotomy in Essential Tremor (REAL-BI-FUS) (P2-17.001)2026
  5. 5Magnetic resonance–guided focused ultrasound for the management of tremor: update on the position statement of the American Society for Stereotactic and Functional Neurosurgery2026