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June 13, 2026Chinese Herbal MedicinesOpen Access

Changyanning Granule alleviates DSS-induced ulcerative colitis in mice by regulating gut microbiota, MAPK pathway and intestinal epithelial barrier

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Authors

ZSZiqi SunMYMingyuan YuanXWXiaoli Wang

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Overview

Randomized trial demonstrates that Changyanning Granule alleviates ulcerative colitis in mice, highlighting its potential therapeutic effects.

Key Points

  • This study aims to investigate the protective effects of Changyanning Granule on DSS-induced ulcerative colitis in mice and explore its underlying mechanisms.
  • Established a mouse colitis model using 3% DSS.
  • Assessed disease activity index and performed histopathological evaluations.
  • Analyzed gut microbiota and inflammatory markers using various biochemical assays.
  • CYNG treatment significantly decreased the disease activity index (DAI) in DSS-induced colitis mice.
  • Restored intestinal barrier function and reduced colonic inflammation observed.
  • Regulated MAPK pathway by inhibiting p-p38 and p-JNK protein levels.

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f0561fbhttps://doi.org/10.1016/j.chmed.2026.06.001
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